Repurposing Ketamine in Depression and Related Disorders: Can This Enigmatic Drug Achieve Success?

Repurposing ketamine in the therapy of depression could well represent a breakthrough understanding etiology depression. Ketamine was originally used as an anesthetic drug and later its use extended to other therapeutic applications such analgesia treatment addiction. At same time, abuse recreational has generated concern for psychotropic potential long-term effects; nevertheless, fast acting antidepressant treatment-resistant patients boosted interest mechanism action both psychiatry wider area neuroscience. This article provides comprehensive overview actions intends cover: (i) evaluation clinical suicidal behavior; (ii) pediatrics; (iii) description action; (iv) involvement specific brain areas producing (v) interaction with hypothalamic-pituitary-adrenal axis; (vi) effect on neuronal transmission bed nucleus stria terminalis output; (vii) any gender-dependent effects ketamine; (viii) inflammatory processes involved depression; (ix) observed single or repeated administration; (x) adverse cognitive potential. Finally, this review attempts assess whether ketamine’s can improve our knowledge etiopathology be considered actual cure rather than merely aimed control symptoms